Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos

• UEMURA Mami

  Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan

• IGARASHI Hitomi

  Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan

• OZAWA Aisa

  Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan

• TSUNEKAWA Naoki

  Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan

• KUROHMARU Masamichi

  Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan

• KANAI-AZUMA Masami

  Center for Experimental Animals, Tokyo Medical and Dental University, 1–5–45 Yushima, Bunkyo-ku, Tokyo 113–8510, Japan

• KANAI Yoshiakira

  Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan

Bibliographic Information

Other Title

• Anatomy : Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos

Abstract

In early embryogenesis, the posteroventral foregut endoderm gives rise to the budding endodermal organs including the liver, ventral pancreas and gallbladder during early somitogenesis. Despite the detailed fate maps of the liver and pancreatic progenitors in the mouse foregut endoderm, the exact location of the gallbladder progenitors remains unclear. In this study, we performed a DiI fate-mapping analysis using whole-embryo cultures of mouse early somite-stage embryos. Here, we show that the majority of gallbladder progenitors in 9–11-somite-stage embryos are located in the lateral-most domain of the foregut endoderm at the first intersomite junction level along the anteroposterior axis. This definition of their location highlights a novel entry point to understanding of the molecular mechanisms of initial specification of the gallbladder.

Journal

• Journal of Veterinary Medical Science

  Journal of Veterinary Medical Science 77 (5), 587-591, 2015

  JAPANESE SOCIETY OF VETERINARY SCIENCE

Keywords

• fate mapping
• foregut
• gallbladder
• mouse

Details

• CRID: 1390282681406616064
• NII Article ID: 130005071872
• NII Book ID: AA10796138
• DOI: 10.1292/jvms.14-0635
• ISSN: 13477439
• ISSN: 09167250
• NDL BIB ID: 026448433
• PubMed: 25648459
• Web Site: http://id.ndl.go.jp/bib/026448433
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026448433
• Web Site: https://search.jamas.or.jp/link/ui/2016026405
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed