Effects of the 5-HT₁A Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats

• Tsutsui Ryuki

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Shinomiya Kazuaki

  Department of Clinical Psycho-Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Sendo Toshiaki

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Kitamura Yoshihisa

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Kamei Chiaki

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women’s University

書誌事項

タイトル別名

• Effects of the 5-HT_1A Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats

抄録

The aim of this study was to compare the effect of the serotonin (5-HT)_1A receptor agonist tandospirone versus that of the benzodiazepine hypnotic flunitrazepam in a rat model of long-term adrenocorticotropic hormone (ACTH)-induced sleep disturbance. Rats implanted with electrodes for recording electroencephalogram and electromyogram were injected with ACTH once daily at a dose of 100 µg/rat. Administration of ACTH for 10 d caused a significant increase in sleep latency, decrease in non-rapid eye movement (non-REM) sleep time, and increase in wake time. Tandospirone caused a significant decrease in sleep latency and increase in non-REM sleep time in rats treated with ACTH. The effect of tandospirone on sleep patterns was antagonized by the 5-HT_1A receptor antagonist WAY-100635. In contrast, flunitrazepam had no significant effect on sleep parameters in ACTH-treated rats. These results clearly indicate that long-term administration of ACTH causes sleep disturbance, and stimulating the 5-HT_1A receptor by tandospirone may be efficacious for improving sleep in cases in which benzodiazepine hypnotics are ineffective.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 38 (6), 884-888, 2015

  公益社団法人 日本薬学会

キーワード

• sleep disturbance
• adrenocorticotropic hormone
• serotonin (5-HT)_1A receptor
• gamma-aminobutyric acid

詳細情報

• CRID: 1390001204634030592
• NII論文ID: 130005072657
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b14-00887
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 026408326
• PubMed: 26027828
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026408326
• Web Site: https://www.jstage.jst.go.jp/article/bpb/38/6/38_b14-00887/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016026449
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可