Salvia Miltiorrhiza Bge.f.alba Ameliorates the Progression of Monocrotaline-Induced Pulmonary Hypertension by Protecting Endothelial Injury in Rats
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- Wang Yun
- Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University
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- Cao Shao-Hua
- Pharmacy Department of Affiliated Hospital of Yan’an University
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- Cui Ying-Jie
- Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University
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- Kong Le-Kai
- Department of Traditional Chinese Internal Medicine, Shandong University of Traditional Chinese Medicine
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- Tian Hua
- Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University
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- Cai Hong-Xin
- Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University
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- Wu Ya-Ping
- Province Key Laboratory of Oral and Maxillofacial, Head and Neck Medical Biology Laboratory, Liaocheng People’s Hospital, Taishan Medical University Department of Clinical Chemistry and Haematology, University Medical Center Utrecht
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- Han Ji-Ju
- Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University
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- Zhao Xiao-Min
- Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University
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- Xia Zuo-Li
- Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University
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抄録
Pulmonary hypertension (PH) is a life-threatening disease that is characterized by elevated pulmonary blood pressure, abnormally thickened pulmonary arteries, and right ventricular hypertrophy. Monocrotaline (MCT) has been used to generate an experimental model of PH in rats, with PH initiated from injuries of lung vascular endothelium. Salvia Miltiorrhiza Bge.f.alba is a widely used traditional herb in China, known to exert protective effects on vascular endothelial cell injury in animal experiments. However, the role of Salvia Miltiorrhiza Bge.f.alba in PH remains unclear. Thus, we investigated the effects of the aqueous extract of Salvia Miltiorrhiza Bge.f.alba (AESM) on MCT-induced PH and explored the pertinent mechanism. PH was induced in rats by a single subcutaneous injection of MCT (60 mg/kg body weight). Low or high dose (4.6 g/kg or 14 g/kg body weight) of AESM was then administered orally for 21 days to PH rats. Hemodynamic study showed that AESM reduced mean pulmonary artery pressure and improved right ventricle function. Lung pathological analysis revealed that AESM reduced wall thickness and lumen stenosis of pulmonary vessels. Also AESM ameliorated right ventricular hypertrophy. Measurement of biochemical parameters indicated that AESM decreased endothelin-1 and thromboxane A2 in plasma and increased nitrogen monoxide and prostacyclin in the plasma and reduced the increase of transforming growth factor β1 in lung tissue. Our results suggest that AESM may ameliorate the progression of MCT-induced PH in rats, at least in part by its protective effect on endothelial injury. Therefore, Salvia Miltiorrhiza Bge.f.alba could be useful in the treatment of PH.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 236 (2), 155-162, 2015
東北ジャーナル刊行会
