Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri
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- Hashiguchi Shunta
- Department of Neurology, Yokohama City University Medical Center, Japan
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- Momoo Takayuki
- Department of Neurology, Yokohama City University Medical Center, Japan
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- Murohashi Yoko
- Department of Neurology, Yokohama City University Medical Center, Japan
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- Endo Masanao
- Department of Neurology, Yokohama City University Medical Center, Japan
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- Shimamura Megumi
- Department of Neurology, Yokohama City University Medical Center, Japan
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- Kawasaki Takashi
- Department of Neurosurgery, Yokohama City University Medical Center, Japan
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- Kanada Sachie
- Department of Pathology, Yokohama City University Medical Center, Japan
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- Nozawa Akinori
- Department of Pathology, Yokohama City University Medical Center, Japan
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- Tada Mikiko
- Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Japan
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- Koyano Shigeru
- Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Japan
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- Tanaka Fumiaki
- Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Japan
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抄録
A 71-year-old immunocompetent man developed cognitive decline and gait disturbance. Brain magnetic resonance imaging (MRI) revealed bilateral diffuse leukoencephalopathy without a mass lesion. An analysis of the cerebrospinal fluid (CSF) showed elevated levels of interleukin (IL)-10. The condition of the patient progressively deteriorated, and intravenous high-dose steroids proved ineffective. Detection of non-destructive, diffusely infiltrating, large B-cell lymphoma in biopsy and autopsy specimens led to a diagnosis of lymphomatosis cerebri (LC). On serial MRI, the basal ganglia and white matter lesions increased in parallel with the levels of IL-10. These findings suggest that the IL-10 level in the CSF may represent a potentially useful biomarker for the early diagnosis and monitoring of the disease progression in LC.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 54 (12), 1547-1552, 2015
一般社団法人 日本内科学会
