マイクロフロー光反応·イミドイル化反応·アシル化反応を駆使する効率的な有機合成

• 布施 新一郎

  東京工業大学資源化学研究所

• 高橋 孝志

  横浜薬科大学漢方薬学科

書誌事項

タイトル別名

• Efficient Organic Synthesis based on Micro-flow Photo-reaction, Imidoylation, and Acylation
• マイクロフロー光反応・イミドイル化反応・アシル化反応を駆使する効率的な有機合成
• マイクロフロー ヒカリ ハンノウ ・ イミドイルカ ハンノウ ・ アシルカ ハンノウ オ クシ スル コウリツテキ ナ ユウキ ゴウセイ

抄録

Micro-flow synthesis has advantages over conventional batch synthesis such as precise control of the reaction time (<1 sec) and temperature by rapid mixing and high heat and mass transfer. In addition, light-penetration efficiency can be improved in photo-reactions due to the thinness of micro-flow reactors. Moreover, scale-up can be readily achieved with high reproducibility either by continuous running or by numbering up of micro-flow reactors. Increasing number of highly efficient reactions and syntheses have been reported based on micro-flow technology in recent years. We have also developed efficient micro-flow photo-reaction, imidoylation, and acylation by taking the advantages of micro-flow technology. Herein, we wish to report our synthesis of bioactive vitamin D₃, its analogues and α-aryl carbonyl compounds based on the micro-flow photo-reaction as well as the synthesis of diimine ligands for olefin polymerization catalysts and peptides based on the micro-flow imidoylation and acylation.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 73 (5), 442-451, 2015

  公益社団法人 有機合成化学協会

キーワード

• micro-flow
• photo-reaction
• thermal reaction
• imidoylation
• acylation
• natural product
• peptide
• vitamin D
• aurilide
• diimine

詳細情報

• CRID: 1390001205341695488
• NII論文ID: 130005077684
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.73.442
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 026396299
• Web Site: http://id.ndl.go.jp/bib/026396299
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026396299
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可