The Effects of Acid Regurgitation and Dyspepsia on Sleep Quality and Work Productivity of Patients with Laryngopharyngeal Reflux Disease (LPRD)

• Ohta Nobuo

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Suzuki Yusuke

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Kurakami Kazuya

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Chida Kuniaki

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Furukawa Takatoshi

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Nasu Takashi

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Watanabe Tomoo

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Abe Yasuhiro

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Ishida Akihiro

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

• Kakehata Seiji

  Department of Otolaryngology Head and Neck Surgery, Yamagata University School of Medicine

抄録

The objective of the present study was to clarify the efficacy of proton pump inhibitor (PPI) therapy with esomeprazole on symptoms, signs, sleep disturbance and work productivity associated with laryngopharyngeal reflux disease (LPRD). Twenty one patients with LPRD were enrolled in present study and received esomeprazole 20 mg daily for two months. These patients with LPRD were investigated by comparing the frequency scale of gastroesohageal reflux disease (GERD), the laryngopharyngeal reflux symptom score, the objective laryngopharyngeal reflux finding score, the Pittsburg sleep quality index questionnaire and the work productivity and activity impairment questionnaire before and after treatment. We found that the scores of these parameters after treatment were significantly lower than those before treatment.<br>These findings indicate that LPRD might have an influence on the quality of life of affected patients including sleep disturbance and work productivity. PPI treatment might improve the symptoms and signs of LPRD also reduce the sleep disturbance and restores the work productivity of patients with LPRD. Taken together, esomeprazole was shown to be useful for the treatment of patients with LPRD.

収録刊行物

• 耳鼻咽喉科臨床　補冊

  耳鼻咽喉科臨床　補冊 141 (0), 112-113, 2015

  耳鼻咽喉科臨床学会

キーワード

• laryngopharyngeal reflux disease (LPRD)
• proton pump inhibitor
• sleep disturbance
• work disturbance

詳細情報

• CRID: 1390001204325477376
• NII論文ID: 130005077970
• DOI: 10.5631/jibirinsuppl.141.112
• ISSN: 21851557
• ISSN: 09121870
• Web Site: https://search.jamas.or.jp/link/ui/2015308191
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可