口腔扁平上皮癌におけるSCC 抗原の有用性についての検討

DOI Web Site 参考文献1件
  • 石上 享嗣
    総合病院国保旭中央病院歯科・歯科口腔外科
  • 肥後 盛洋
    千葉大学大学院医学研究院臨床分子生物学講座
  • 伏見 一章
    千葉大学大学院医学研究院臨床分子生物学講座
  • 小越 健次
    千葉大学大学院医学研究院臨床分子生物学講座
  • 佐久間 健太郎
    千葉大学大学院医学研究院臨床分子生物学講座
  • 西尾 可苗
    千葉大学大学院医学研究院臨床分子生物学講座
  • 椎葉 正史
    千葉大学大学院医学研究院臨床分子生物学講座
  • 鵜澤 一弘
    千葉大学大学院医学研究院臨床分子生物学講座
  • 秋葉 正一
    総合病院国保旭中央病院歯科・歯科口腔外科
  • 丹沢 秀樹
    千葉大学大学院医学研究院臨床分子生物学講座

書誌事項

タイトル別名
  • A study of the usefulness of SCC antigen for oral squamous cell carcinoma
  • コウコウ ヘンペイ ジョウヒガン ニ オケル SCC コウゲン ノ ユウヨウセイ ニ ツイテ ノ ケントウ

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抄録

To evaluate the usefulness of squamous cell carcinoma　（SCC） antigen for screening, prognosis, monitoring the response to surgical treatment, and early detection of recurrence and metastases from oral squamous cell carcinoma　（OSCC）, we investigated the time course of serum levels of SCC antigen in 156 patients with OSCC.<br>Elevated serum SCC antigen levels were detected in 35 of the 156 patients with OSCC. Preoperative positive rates were low　（22%）. The higher the serum SCC antigen level, the larger was the primary tumor, and the clinical stage and cervical lymph-node metastasis were also more advanced. In patients who tested positive for serum SCC antigen before operation, the serum SCC antigen levels significantly declined after surgery. The SCC antigen level in the recurrent or metastatic group was significantly higher than that in the non-recurrent and non-metastatic group. Receiver operating characteristic　（ROC） curve analysis identified the optimal cut-off value　（1.34 ng/mL） of the preoperative serum SCC antigen to predict recurrence or metastasis of OSCC. The SCC antigen level immediately before the detection of recurrence or metastasis was significantly higher than the mean value after surgery. The optimal cut-off value　（1.40 ng/mL） of the postoperative serum SCC antigen level for suspecting recurrence or metastasis of OSCC was identified by ROC curve analysis.<br>Our results suggested that the SCC antigen level is related to an increase in tumor volume, metastasis to cervical lymph nodes, and clinical stage. SCC antigen might be a useful prognostic factor. The SCC antigen level might be a useful for evaluating the efficacy of treatments in SCC antigen-positive cases and may facilitate the early detection of recurrence, metastasis, or both. However, because the clinical value of serum SCC antigen as a screening factor for OSCC is low, it might be an auxiliary tool for the screening of OSCC.

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