Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation
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- Yoshihara Takuma
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Shimada Kazunori
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Fukao Kosuke
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Sai Eiryu
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Sato-Okabayashi Yayoi
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Matsumori Rie
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Shiozawa Tomoyuki
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Alshahi Hamad
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Miyazaki Tetsuro
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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- Tada Norihiro
- Atopy Research Center, Juntendo University Graduate School of Medicine
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- Daida Hiroyuki
- Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine
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Background:Dietary intake of ω3 polyunsaturated fatty acids (ω3-PUFAs) reduces progression of atherosclerosis and prevents future cardiovascular events. Macrophages are key players in the pathogenesis of aortic aneurysm. The effects of ω3-PUFAs on abdominal aortic aneurysm (AAA) formation and macrophage-mediated inflammation remain unclear.Methods and Results:The AAA model was developed by angiotensin II infusion in apolipoprotein E-deficient mice. Mice were supplemented with eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). The development of AAA lesions and macrophage infiltration in the aorta were analyzed. Gene expression of inflammatory markers in aortic tissues and peritoneal macrophages were measured by using quantitative polymerase chain reaction. AAA formation and macrophage infiltration were significantly suppressed after EPA and DHA administration. EPA administration and DHA administration significantly decreased the expression of tumor necrosis factor-α, monocyte chemoattractant protein-1, transforming growth factor-β, matrix metalloproteinases (MMP)-2, MMP-9, and vascular cell adhesion molecule-1 in the aortas. The expression of arginase 2, which is a marker of pro-inflammatory macrophages, was significantly lower and that of Ym1, which is a marker of anti-inflammatory macrophages, and was significantly higher after EPA and DHA administration. The same trends were observed in peritoneal macrophages after EPA and DHA administration.Conclusions:Dietary intake of EPA and DHA prevented AAA development through the inhibition of aortic and macrophage-mediated inflammation. (Circ J 2015; 79: 1470–1478)
収録刊行物
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- Circulation Journal
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Circulation Journal 79 (7), 1470-1478, 2015
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205106950912
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- NII論文ID
- 130005083946
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 026523487
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- PubMed
- 25925976
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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