Comparison of Long-Term Clinical Outcomes after Drug-Eluting Stent Implantation in Patients with Coronary Artery Disease with and without Prior Cerebral Infarction

• Sasao Hisataka

  Departments of Cardiology, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan

• Fujiwara Hidetoshi

  Departments of Neurosurgery, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan

• Horiuchi Naruyoshi

  Departments of Neurosurgery, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan

• Shirasaki Shuichi

  Departments of Anesthesiology, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan

• Sakai Ichiro

  Departments of Anesthesiology, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan

• Tsuchida Kazuyuki

  Departments of Neurosurgery, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan

• Murai Hiroshi

  Departments of Neurosurgery, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan

抄録

Objective: To compare the clinical and angiographic outcomes after implantation of drug-eluting stents (DESs) in patients with coronary artery disease (CAD) with or without prior cerebral infarction.Materials and Methods: Ninety-eight consecutive patients (130 lesions) who underwent successful coronary DES implantation were prospectively classified into two groups: those with a clinical history of symptomatic cerebral infarction (cerebral infarction group, 49 patients, 69 lesions) and those without a clinical history of symptomatic cerebral infarction (noncerebral infarction group, 49 patients, 61 lesions). The primary endpoint was defined as death, nonfatal myocardial infarction, and cerebrovascular events.Results: The Kaplan–Meier method was used to create a primary endpoint curves to determine the time-dependent cumulative primary endpoint-free rate, which were compared using the log-rank test. The incidence of primary endpoints was higher in the cerebral infarction group than in the noncerebral infarction group (p = 0.0075). The Cox proportional hazards regression model for primary endpoint identified prior cerebral infarction (p = 0.0331, hazard ratio = 2.827) and patients with peripheral artery disease (p = 0.0271, hazard ratio = 2.757) as explanatory factors.Conclusion: The results showed that clinical outcomes were poorer in patients with CAD who had prior cerebral infarctions than in those who did not have infarction.

収録刊行物

• Annals of Vascular Diseases

  Annals of Vascular Diseases 8 (2), 79-86, 2015

  Annals of Vascular Diseases 編集委員会

キーワード

• cerebral infarction
• coronary artery disease
• drug-eluting stents
• clinical outcome

詳細情報

• CRID: 1390282680251288576
• NII論文ID: 130005084189
• DOI: 10.3400/avd.oa.14-00137
• ISSN: 18816428
• ISSN: 1881641X
• Web Site: https://www.jstage.jst.go.jp/article/avd/8/2/8_oa.14-00137/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016128027
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
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