Synthesis and Anti-microbial Activity of Novel Phosphatidylethanolamine-N-amino Acid Derivatives
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- Vijeetha Tadla
- Centre for Lipid Research, CSIR-Indian Institute of Chemical Technology
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- Balakrishna Marrapu
- Centre for Lipid Research, CSIR-Indian Institute of Chemical Technology
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- Lakshmi Karuna Mallampalli Sri
- Centre for Lipid Research, CSIR-Indian Institute of Chemical Technology
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- Koppeswara Rao Bhamidipati Venkata Surya
- Centre for Lipid Research, CSIR-Indian Institute of Chemical Technology
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- Narayana Prasad Rachapudi Badari
- Centre for Lipid Research, CSIR-Indian Institute of Chemical Technology
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- Kumar Koochana Pranay
- Chemical Biology Laboratory, CSIR-Indian Institute of Chemical Technology
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- Narayana Murthy Upadyaula Surya
- Chemical Biology Laboratory, CSIR-Indian Institute of Chemical Technology
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The study involved synthesis of five novel amino acid derivatives of phosphatidylethanolamine isolated from egg yolk lecithin employing a three step procedure i) N-protection of L-amino acids with BOC anhydride in alkaline medium ii) condensation of - CO2H group of N-protected amino acid with free –NH2 of PE by a peptide linkage and iii) deprotection of N-protected group of amino acids to obtain phosphatidylethanolamine-N-amino acid derivatives in 60-75% yield. The five L-amino acids used were L glycine, L-valine, L-leucine, L-isoleucine and L-phenylalanine. The amino acid derivatives were screened for anti-baterial activity against B. subtilis, S. aureus, P. aeroginosa and E. coli taking Streptomycin as reference compound and anti-fungal activity against C. albicans, S. cervisiae, A. niger taking AmphotericinB as reference compound. All the amino acid derivatives exhibited extraordinary anti-bacterial activities about 3 folds or comparable to Streptomycin and moderate or no anti-fungal activity against Amphotericin-B.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 64 (7), 705-712, 2015
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679068021760
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- NII論文ID
- 130005085911
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 026523299
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- PubMed
- 25994558
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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