Enhances the invasiveness of cancer cells into 3D collagen matrices

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  • Iguchi Yuta
    Faculty of Advanced Life Science, Hokkaido University
  • Ishihara Seiichiro
    Faculty of Advanced Life Science, Hokkaido University Research Center for Cooperative Projects, Graduate School of Medicine, Hokkaido University
  • Uchida Yoshimi
    Faculty of Advanced Life Science, Hokkaido University
  • Tajima Kaori
    Faculty of Advanced Life Science, Hokkaido University
  • Mizutani Takeomi
    Faculty of Advanced Life Science, Hokkaido University
  • Kawabata Kazushige
    Faculty of Advanced Life Science, Hokkaido University
  • Haga Hisashi
    Faculty of Advanced Life Science, Hokkaido University Research Center for Cooperative Projects, Graduate School of Medicine, Hokkaido University

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タイトル別名
  • Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices

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Numerous types of cancer cells migrate into extracellular tissues. This phenomenon is termed invasion, and is associated with poor prognosis in cancer patients. In this study, we demonstrated that filamin B (FLNb), an actin-binding protein, is highly expressed in cancer cell lines that exhibit high invasiveness, with a spindle morphology, into 3D collagen matrices. In addition, we determined that knockdown of FLNb in invasive cancer cells converts cell morphology from spindle-shaped, which is associated with high invasiveness, to round-shaped with low invasiveness. Furthermore, di-phosphorylation of myosin regulatory light chain (MRLC) and phosphorylation of focal adhesion kinase (FAK) are inhibited in FLNb-knockdown cancer cells. These results suggest that FLNb enhances invasion of cancer cells through phosphorylation of MRLC and FAK. Therefore, FLNb may be a new therapeutic target for invasive cancers.

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