Immune-mediated Neuropathy with Anti-disialosyl IgM Antibodies in Diffuse Large B-cell Lymphoma: A Case Report and Literature Review
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- Shihashi Gen
- Department of Neurology, Keio University School of Medicine, Japan
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- Yagi Takuya
- Department of Neurology, Keio University School of Medicine, Japan
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- Suzuki Shigeaki
- Department of Neurology, Keio University School of Medicine, Japan
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- Seki Morinobu
- Department of Neurology, Keio University School of Medicine, Japan
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- Kohashi Sumiko
- Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
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- Ueda Tomoki
- Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
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- Kameyama Kaori
- Department of Pathology, Keio University School of Medicine, Japan
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- Kusunoki Susumu
- Department of Neurology, Kinki University School of Medicine, Japan
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- Nakajima Hideaki
- Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
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- Okamoto Shinichiro
- Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
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- Suzuki Norihiro
- Department of Neurology, Keio University School of Medicine, Japan
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抄録
A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). He was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and received high-dose intravenous immunoglobulin for the treatment of neuropathy. After initiating the treatments, the patient's neurological impairment improved dramatically. He currently remains in complete remission without a flare-up of the polyneuropathy. Based upon our experience and other case reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we conclude that determining the anti-ganglioside antibody profile and beginning early treatment should be considered promptly for patients with malignant lymphoma who develop polyneuropathy.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 54 (13), 1647-1651, 2015
一般社団法人 日本内科学会