IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics

DOI Web Site PubMed 被引用文献2件 参考文献63件
  • Watanabe Takashi
    Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine
  • Wang Shujie
    Department of Neural Regeneration and Cell Communication, Mie University, Graduate School of Medicine
  • Kaibuchi Kozo
    Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine

この論文をさがす

抄録

The actin-cytoskeleton plays a critical role in various biological processes, including cell migration, development, tissue remodeling, and memory formation. Both extracellular and intracellular signals regulate reorganization of the actin-cytoskeleton to modulate tissue architecture and cellular morphology in a spatiotemporal manner. Since the discovery that activation of Rho family GTPases induces actin-cytoskeleton reorganization, the mode of action of Rho family GTPases has been extensively studied and individual effectors have been characterized. The actin-binding protein IQGAP1 was identified as an effector of Rac and Cdc42 and is the founding member of the IQGAP family with two additional isoforms. The IQGAP family shows conserved domain organization, and each member displays a specific expression pattern in mammalian tissues. IQGAPs regulate the actin-cytoskeleton alone and with their binding partners, thereby controlling diverse cellular processes, such as cell migration and adhesion. Here, we introduce IQGAPs as an actin-cytoskeleton regulator.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (63)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ