Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks
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- Honda Kazuhisa
- Graduate School of Agricultural Science, Kobe University, Japan
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- Shimatani Tomohiko
- Graduate School of Agricultural Science, Kobe University, Japan
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- Aoki Koji
- Graduate School of Agricultural Science, Kobe University, Japan
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- Yamaguchi Takuya
- Graduate School of Agricultural Science, Kobe University, Japan
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- Kondo Makoto
- Faculty of Agriculture, Kobe University, Japan
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- Saneyasu Takaoki
- Graduate School of Agricultural Science, Kobe University, Japan
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- Kamisoyama Hiroshi
- Graduate School of Agricultural Science, Kobe University, Japan
Bibliographic Information
- Other Title
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- Glucagon-like peptide-2 functions as anorexigenic peptide not only in the central nervous system but also in the peripheral circulation in broiler chicks
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Abstract
Brain-gut peptides play important roles in the appetite regulatory system in mammals. Glucagon-like peptide (GLP)-1, GLP-2, and oxyntomodulin (OXM) are processed from the same precursor, proglucagon, in both brain and intestines in mammals and birds. We previously showed that intracerebroventricular administration of these three peptides significantly suppressed food intake in chicks. However, peripheral roles of chicken GLP-2 have not yet been investigated, although GLP-2 plays important roles both in central and peripheral regulation of food intake in mammals. The aim of this study is to investigate whether GLP-2 functions as an anorexigenic peptide in both brain and peripheral circulation in chicks. Intracerebroventricular administration of GLP-2 significantly suppressed food intake in chicks. Twenty-four hours of fasting significantly decreased the mRNA level of proglucagon in the medulla oblongata of chicks. These results suggest that GLP-2 functions as anorexigenic peptides in the central nervous system in chicks. In addition, intravenous administration of GLP-2 significantly suppressed food intake in chicks. Lines of evidence suggest that dietary nutrients stimulate the secretion of GLP-2 from L cells in the small intestine in chickens. These findings suggest that GLP-2 functions as both central and peripheral anorexigenic signals in chicks.
Journal
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- The Journal of Poultry Science
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The Journal of Poultry Science 52 (3), 183-187, 2015
Japan Poultry Science Association
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Details 詳細情報について
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- CRID
- 1390282680183699328
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- NII Article ID
- 130005089398
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- NII Book ID
- AA11564513
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- ISSN
- 13490486
- 13467395
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- NDL BIB ID
- 026604982
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed