Plasma amino acid profiles at various reproductive stages in female rats
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- OKAME Rieko
- Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889–2192, Japan
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- NAKAHARA Keiko
- Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889–2192, Japan
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- MURAKAMI Noboru
- Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889–2192, Japan
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We measured the plasma levels of amino acids at various reproductive stages in female rats, including the estrous cycle, pregnancy and lactation, and compared the resulting amino acid profiles using two- or three-dimensional figures. These figures revealed that the amino acid profiles of pregnant and lactating dams differed considerably from those during the estrous cycle or in male rats. The plasma levels of individual amino acids were almost the same between proestrus, estrus, metestrus and diestrus, and their profiles did not differ significantly. However, the amino acid profiles changed during pregnancy and lactation in dams. The plasma Ser level decreased significantly in mid and late pregnancy, whereas Tyr, Gly and His decreased significantly in the late and end stages of pregnancy, and Trp and Lys significantly decreased and increased at the end of pregnancy, respectively. Much larger changes in amino acid profiles were observed during lactation, when the levels of many amino acids increased significantly, and none showed a significant decrease. Plasma Pro, Ser and Gly levels increased continuously from day 1 until day 15 of lactation, whereas Asn and Met increased significantly from days 1 and 5 respectively until the end of lactation. These results suggest that the profiles of plasma amino acids show characteristic changes according to reproductive stage and that it may be necessary to consider such differences when performing amino acid-based diagnosis.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 77 (7), 815-821, 2015
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206428572032
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- NII論文ID
- 130005089944
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 026635412
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- PubMed
- 25787929
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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