Synthesis of Novel Pyrido[1,2-a]pyrimidine-3-carboxamide Derivatives and Their Anticancer Activity
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- Santhosh Kumar Gautham
- Fluoroorganic Division, Indian Institute of Chemical Technology
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- Jitender Dev Gaddameedi
- Fluoroorganic Division, Indian Institute of Chemical Technology
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- Ravi Kumar Nagiri
- Fluoroorganic Division, Indian Institute of Chemical Technology
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- Krishna Swaroop Desireddy
- Fluoroorganic Division, Indian Institute of Chemical Technology
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- Poorna Chandra Yedla
- Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology
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- Ganesh Kumar Chityala
- Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology
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- Narsaiah Banda
- Fluoroorganic Division, Indian Institute of Chemical Technology
書誌事項
- タイトル別名
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- Synthesis of Novel Pyrido[1,2-<i>a</i>]pyrimidine-3-carboxamide Derivatives and Their Anticancer Activity
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A series of novel pyrido[1,2-a]pyrimidine-3-carboxamide derivatives 6a–n were prepared starting from 2(1H) pyridone 1 via hydrolysis, de-carboxylation, selective O-alkylation followed by rearrangement to give pyridine-2-amine 3. Compound 3 on reaction with ethoxy methylene malonic diethyl ester (EMME) under a conventional method followed by cyclization under micro wave irradiation (MWI) conditions resulted in product 5. Compound 5 on coupling with diverse substituted aliphatic amines formed title compounds 6a–n. All the products 6a–n were screened against four human cancer cell lines and compounds 6h–k and n which showed promising anticancer activity have been identified.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 63 (8), 584-590, 2015
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679153874304
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- NII論文ID
- 130005090113
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 026616838
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- PubMed
- 26235166
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可