Destabilization of phase-separated structures in local anesthetic-containing model biomembranes

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著者

    • Sugahara Ko
    • School of Materials Science, Japan Advanced Institute of Science and Technology
    • Shimokawa Naofumi
    • School of Materials Science, Japan Advanced Institute of Science and Technology
    • Takagi Masahiro
    • School of Materials Science, Japan Advanced Institute of Science and Technology

抄録

We observed the phase behaviors, and the changes of membrane fluidity in lipid membranes containing local anesthetics (LAs), lidocaine and tetracaine. The phase separation in DOPC/DPPC binary membranes had not been changed significantly by addition of LAs, whereas that in DOPC/DPPC/Chol ternary membranes were suppressed by LAs. In order to evaluate the membrane fluidity, Laurdan generalized polarization values of membranes were measured. The fluidity of DOPC-rich phase in the ternary membrane became lower as LAs concentration had increased. Our results indicated the correlation between physical property change on membrane and pharmacological functions of LAs.

収録刊行物

  • Chemistry Letters

    Chemistry Letters advpub(0), 2015

    The Chemical Society of Japan

各種コード

  • NII論文ID(NAID)
    130005092611
  • 本文言語コード
    EN
  • ISSN
    0366-7022
  • データ提供元
    J-STAGE 
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