Multifocal Fibrosclerosis with Hypertrophic Pachymeningitis and a Soft Tissue Mass around the Thoracic Vertebral Bodies: A Case Report with Review of the Literature

  • Sato Mitsuto
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
  • Kodaira Minori
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
  • Ishii Wataru
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
  • Nakagawa Michitaka
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
  • Kishida Dai
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
  • Miyazaki Daigo
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
  • Shimojima Yasuhiro
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
  • Matsuda Masayuki
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
  • Uehara Takeshi
    Department of Laboratory Medicine, Shinshu University School of Medicine, Japan
  • Ikeda Shu-ichi
    Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan

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抄録

Multifocal fibrosclerosis is the term used to represent a combination of similar fibrous lesions occurring at different anatomical sites. We herein report a hypertrophic pachymeningitis patient with a soft tissue mass around the thoracic vertebral bodies. A histopathological analysis of the biopsied tissues from both lesions showed dense fibrosis and a marked infiltration of lymphocytes and plasma cells, which lead to the diagnosis of multifocal fibrosclerosis. This pathological condition closely resembles that of IgG4-related disease and is a very rare combination of manifestations. Our case suggests that hypertrophic pachymeningitis patients need to also undergo a whole body examination.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 54 (17), 2267-2272, 2015

    一般社団法人 日本内科学会

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