Arsenic (+3 Oxidation State) Methyltransferase（AS3MT）遺伝子多型と無機ヒ素のメチル化能力との関連

• 阿草 哲郎

  愛媛大学沿岸環境科学研究センター 現所属：熊本県立大学環境共生学部環境資源学科

• 國頭 恭

  信州大学理学部物質循環学科

• TUE Nguyen Minh

  愛媛大学沿岸環境科学研究センター

• LAN Vi Thi Mai

  Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam

• MINH Tu Binh

  Faculty of Chemistry, Hanoi University of Science, Vietnam National University, Vietnam

• TRANG Pham Thi Kim

  Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam

• 藤原 純子

  島根大学医学部法医学講座

• 竹下 治男

  島根大学医学部法医学講座

• 高橋 真

  愛媛大学農学部生物環境保全学

• VIET Pham Hung

  Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam

• 田辺 信介

  愛媛大学沿岸環境科学研究センター

• 岩田 久人

  愛媛大学沿岸環境科学研究センター

書誌事項

タイトル別名

• Relationship between Arsenic (+3 Oxidation State) Methyltransferase Genetic Polymorphisms and Methylation Capacity of Inorganic Arsenic
• Arsenic (+3 Oxidation State) Methyltransferase (AS3MT)イデンシ タケイ ト ムキ ヒソ ノ メチルカ ノウリョク ト ノ カンレン

抄録

Arsenic metabolism affects the susceptibility of humans to arsenic toxicity; therefore, clarification of the factors associated with individual variations in arsenic metabolism is an important task. Genetic polymorphisms such as single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT), which can methylate arsenic compounds using S-adenosyl-l-methionine (AdoMet), have been reported to modify arsenic methylation. In this review, we summarize studies conducted by us in Vietnam and by others on the association of AS3MT genetic polymorphisms with arsenic metabolism as well as human health effects. Most of the SNPs in AS3MT showed inconsistent results in terms of genotype-dependent differences in arsenic metabolism among the studies. However, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the study population: AS3MT 12390 (rs3740393) affected the second step of methylation of arsenic, whereas 14458 (rs11191439) affected the first methylation step.

収録刊行物

• 日本衛生学雑誌

  日本衛生学雑誌 70 (3), 186-196, 2015

  一般社団法人日本衛生学会

キーワード

• ヒ素
• 3価ヒ素メチル転移酵素（AS3MT）
• 遺伝子多型
• メチル化能

詳細情報

• CRID: 1390282681338738304
• NII論文ID: 130005098973
• NII書誌ID: AN00185923
• DOI: 10.1265/jjh.70.186
• ISSN: 18826482
• ISSN: 00215082
• NDL書誌ID: 026796335
• PubMed: 26411936
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026796335
• Web Site: https://www.jstage.jst.go.jp/article/jjh/70/3/70_186/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016051588
• 本文言語コード: ja
• データソース種別:
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  • Crossref
  • PubMed
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