Presence of Nitric Oxide-Sensing Systems in the Human Pathogen <i><i>Vibrio vulnificus</i></i>

• ELGAML ABDELAZIZ

  Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Microbiology and Immunology Department, Faculty of Pharmacy, Mansoura University

• MIYOSHI SHIN-ICHI

  Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

抄録

Vibrio vulnificus is a halophilic estuarine bacterium, but this species causes fatal septicemia in humans. V. vulnificus may encounter many kinds of stresses either in the natural environment or in the human body. One of the striking stresses is the exposure to the reactive oxygen species including nitric oxide (NO). The present study revealed that NO could participate in the regulation of the V. vulnificus community behavior. When the bacterium was cultivated in the presence of sub-lethal doses of an NO donor, the expression of the genes encoding NO-detoxifying enzymes was significantly increased. The NO donor was also found to cause significant increase in production of a metalloprotease, a putative virulence factor, by the bacterium.

収録刊行物

• Ｂｉｏｃｏｎｔｒｏｌ　Ｓｃｉｅｎｃｅ

  Ｂｉｏｃｏｎｔｒｏｌ　Ｓｃｉｅｎｃｅ 20 (3), 199-203, 2015

  日本防菌防黴学会

キーワード

• <I>Vibrio vulnificus</I>
• Nitric oxide
• Oxidative stress
• Detoxification

詳細情報

• CRID: 1390001204463969280
• NII論文ID: 130005099336
• NII書誌ID: AA11169621
• DOI: 10.4265/bio.20.199
• ISSN: 18840205
• ISSN: 13424815
• PubMed: 26412700
• Web Site: https://ousar.lib.okayama-u.ac.jp/56681
• Web Site: https://www.jstage.jst.go.jp/article/bio/20/3/20_199/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016154620
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可