Suture materials affect peri-implant bone healing and implant osseointegration
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- Villa Oscar
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo
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- P. Lyngstadaas Staale
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo
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- Monjo Marta
- Group of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences (IUNICS), University of Balearic Islands
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- Satué Maria
- Group of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences (IUNICS), University of Balearic Islands
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- J. Rønold Hans
- Department of Prosthodontics, Institute of Clinical Dentistry, University of Oslo
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- Petzold Christiane
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo
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- C. Wohlfahrt Johan
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo
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The aim of this study was to evaluate the effects of the remnants of two suture materials on osseointegration of titanium implants in a rabbit tibial model. Calibrated defects were prepared in the tibia of five Chinchilla rabbits. Filaments of nonresorbable (NR) nylon or resorbable (R) chitosan were placed at the bone to implant interface, whereas control sites had no suture material. After a healing period of 4 weeks, a pull-out test procedure was performed followed by enzymatic analyses of the wound fluid and relative quantification of mRNA levels for bone-related and cytokine markers from the peri-implant bone. A trend toward a reduced pull-out force was observed in the NR group (NR: 23.0 ± 12.8 N; R: 33.9 ± 11.3 N; control: 33.6 ± 24.0 N). Similarly, the bone resorption marker vacuolar type H+-ATPase was increased in the NR group compared with that in the control group (P = 0.041). The R group showed trends for lower alkaline phosphatase activity and osteocalcin expression and higher total protein content and RNA compared with the control group. In this submerged healing model, peri-implant bone healing was marginally affected by the two suture materials tested. However, there was a tendency toward better osseointegration and lower expression of bone resorption markers in the R group compared with the control group. (J Oral Sci 57, 219-227, 2015)
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ
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Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ 57 (3), 219-227, 2015
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