Feasibility study of a sinusoidal shear flow generator for using counter-oscillating flow fields in monitoring of individual red blood cells under shear flow conditions

DOI Web Site 被引用文献1件 参考文献26件
  • Watanabe Nobuo
    Dept. of Bio-Science and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology
  • Tsuzuki Tatsuya
    Dept. of Bio-Science and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology
  • Suzuki Yusuke
    Dept. of Bio-Science and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology

この論文をさがす

抄録

Aim: To develop a prototype device that allows direct observation of the deformation of individual red blood cells (RBCs) in an oscillating shear flow field.<br>Method: A counter-oscillation mechanism composed of two parallel glass plates was constructed to keep RBCs floating at the centerline of a 30 μm fluid gap. RBCs in the suspension fluid were observed using a high-speed camera with 40-fold magnification.<br>Results: RBCs remained within the camera’s field of view when exposed to a shear force field that oscillated at 2 Hz. Moreover, glutaraldehyde-treated, hardened RBCs always tumbled and low-density RBCs had a larger elongation than high-density RBCs when exposed to the same shear field.<br>Conclusion: The feasibility of this counter-oscillating mechanism for evaluating RBC deformability has been demonstrated.

収録刊行物

  • Journal of Biorheology

    Journal of Biorheology 29 (1), 36-41, 2015

    特定非営利活動法人 日本バイオレオロジー学会

被引用文献 (1)*注記

もっと見る

参考文献 (26)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ