ドラッグ・リポジショニングによる抗癌剤・放射線耐性克服薬ならびに転移抑制薬の開発

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  • Development of medicines for enhancing chemo-sensitivity and radio-sensitivity and uppression of metastasis of cancer cells by drug repositioning method
  • ドラッグ ・ リポジショニング ニ ヨル コウガンザイ ・ ホウシャセン タイセイ コクフクヤク ナラビニ テンイ ヨクセイヤク ノ カイハツ

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In order to understand the mechanism of chemo-resistance and radio-resistance in cancer treatment, micro-array analyses using several combinations of sensitive cells and resistant cells revealed candidate genes involved in the resistance. Furthermore, one gene with cancer-specific suppressed expression was detected by two-dimensional electrophoresis and time-of-flight mass (TOF MS) spectrometer resolution using normal cells and cancer cells in the oral epithelium, and its suppressive role in tumor metastasis was confirmed by the relationship between the gene expression status and the lymph-node metastasis and genetic function analyses. These genes were focused on as targeting genes in anticancer treatment.<br>In order to develop medicines for enhancing chemo-sensitivity and radio-sensitivity and to suppress metastasis of cancer cells, the drug repositioning method, which involves identifying and developing new uses for existing drugs, was used and several candidate drugs for clinical medicine were found. Finally, several drugs were narrowed down as possible clinical medicines by in vitro and in vivo functional analyses.

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