Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque
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- Toshikuni Nobuyuki
- Department of Hepatology, Kanazawa Medical University
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- Asaji Takayoshi
- Health Evaluation Center, Kanazawa Medical University
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- Nakanishi Yumiko
- Health Evaluation Center, Kanazawa Medical University
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- Nagasawa Shin-ya
- Health Evaluation Center, Kanazawa Medical University Department of Epidemiology and Public Health, Kanazawa Medical University
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- Uenishi Hiroaki
- Department of General Internal Medicine, Kanazawa Medical University
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- Tsutsumi Mikihiro
- Department of Hepatology, Kanazawa Medical University
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Aim: There is a strong relationship between carotid atherosclerosis and future cardiovascular disease (CVD). This study sought to clarify the association of fatty liver and an elevated serum gamma-glutamyl transpeptidase (GGT) level with carotid atherosclerosis.<br>Methods: We reviewed the medical records of subjects who underwent medical checkups at our institute. Carotid atherosclerosis and fatty liver were assessed using ultrasound (US), and predictors of increased carotid intima-media thickness (IMT) and carotid plaque were identified using a logistic regression model.<br>Results: In total, 958 subjects (564 men, 394 women; median age, 59 years) were enrolled. The median value of the mean carotid IMT was 0.713 mm, and the frequency of carotid plaque was 19.5%. For the highest quartile of the mean carotid IMT (≥0.863 mm), a male sex, older age, hypertension (HT), dyslipidemia (DL) and type 2 diabetes mellitus (DM) were identified as independent predictors. A male sex, older age, HT and elevated serum GGT level were found to be significant predictors of the presence of carotid plaque. In addition, fatty liver correlated with the existence of carotid plaque. When the combination of the serum GGT level and presence or absence of fatty liver was included as a variable in the analysis, a male sex, older age, HT and fatty liver with a serum GGT level of ≥83 IU/L (90th percentile) (odds ratio 3.21, 95% confidence interval 1.27–8.12, p=0.014)were identified to be significantly associated with carotid plaque.<br>Conclusions: This study suggests that the simultaneous presence of an elevated serum GGT level and fatty liver is highly predictive of carotid plaque.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 22 (10), 1051-1060, 2015
一般社団法人 日本動脈硬化学会
