Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism

• Kobayashi Junji

  Kanazawa Medical University General Internal Medicine

• Miyashita Kazuya

  Immuno-Biological Laboratories Co., Ltd.

• Nakajima Katsuyuki

  Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine

• Mabuchi Hiroshi

  Kanazawa University Graduate School of Pharmaceutical Health Sciences, lipid research course

抄録

Hepatic lipase (HL) is a key enzyme catalyzing the hydrolysis of triglycerides (TG) and phospholipids (PLs) in several lipoproteins. It is generally recognized that HL is involved in the remodeling of remnant, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and the production of small, dense low-density lipoproteins (sd-LDLs).On the other hand, it is unclear whether HL accelerates or retards atherosclerosis. From the clinical point of view, HL deficiency may provide useful information on answering this question, but the rarity of this disease makes it impossible to conduct epidemiological study.In this review, we describe a comprehensive and updated view of the clinical significance of HL on lipid and lipoprotein metabolism.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 22 (10), 1001-1011, 2015

  一般社団法人 日本動脈硬化学会

キーワード

• HDL
• EL
• LPL
• HL deficiency
• Atherosclerosis

詳細情報

• CRID: 1390001204432013056
• NII論文ID: 120006464059
• NII論文ID: 130005101341
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.31617
• DOI: 10.24517/00039969
• ISSN: 18803873
• ISSN: 13403478
• PubMed: 26194979
• Web Site: http://hdl.handle.net/2297/48759
• Web Site: https://www.jstage.jst.go.jp/article/jat/22/10/22_31617/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016248612
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • Crossref
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• 抄録ライセンスフラグ: 使用不可