左顎下部に発症した加齢性Epstein-Barr Virus (EBV) 関連B細胞性リンパ増殖性疾患の1例

DOI Web Site Web Site 参考文献10件
  • 緒方 絹子
    久留米大学医学部歯科口腔医療センター
  • 岩本 修
    久留米大学医学部歯科口腔医療センター
  • 高野 雅代
    久留米大学医学部歯科口腔医療センター
  • 轟 圭太
    久留米大学医学部歯科口腔医療センター 久留米大学医学部病理学講座
  • 古場 朗洋
    久留米大学医学部歯科口腔医療センター
  • 楠川 仁悟
    久留米大学医学部歯科口腔医療センター

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  • A case of age-related Epstein-Barr Virus (EBV) - associated B-cell lymphoproliferative disorder arising in the submandibular region
  • ヒダリ アゴ カブ ニ ハッショウ シタ カレイセイ Epstein-Barr Virus(EBV)カンレン B サイボウセイ リンパ ゾウショクセイ シッカン ノ 1レイ

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Oyama et al.1) reported that age-related Epstein-Barr virus (EBV) -associated B-cell lymphoproliferative disorder (age-related EBV + B-LPD) is a group of clinicopathological entities that predominantly occur in elderly patients and share features of EBV-positive and B-cell neoplasms, arising in immunologically compromised patients despite no evidence of predisposing immunodeficiency. This disease may be associated with an age-related decline in immune function, and the 2008 WHO lymphoma classification now includes EBV-positive diffuse large B-cell lymphoma of the elderly as one subtype of diffuse large B-cell lymphoma (DLBCL). We report a case of the disease arising in the left submandibular region. A 79-year-old man was admitted our hospital because of swelling and pain of the left submandibular region as well as a hoarse voice. We suspected carcinoma of the left submandibular glands or malignant lymphoma on the basis of the laboratory data and imaging findings, and performed an incision biopsy. Histopathologically, infiltration of large atypical lymphoid cells into granulation tissue with marked necrosis was found in the cervical lymph nodes. The neoplastic cells were positive for CD20, CD30, and EBER and negative for CD3 and CD15. Therefore, the patient was given a diagnosis of age-related EBV + B-LPD. He received radiotherapy and target therapy and had remission.

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