本邦におけるB型慢性肝疾患からの肝発癌予測リスクスコアモデル（Japanese risk estimations of HBV-related HCC：JAB-HCC）の作成

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  • A new risk estimation scale of HCC development, named JAB-HCC score (Japanese risk estimations of HBV-related HCC), shows a good discrimination capability

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Chronic hepatitis B virus (HBV) infection leads to cirrhosis and hepatocellular carcinoma (HCC). However, the risk of HCC in each patient is non-uniform. We newly created an easy-to-calculate risk estimation scale of HCC in Japanese untreated chronic hepatitis B (CHB) patients. Our hospital-based cohort (n=1143) in which no patients received antiviral therapy was used to generate a risk scale of HCC development. We generated a new risk scale of HCC development based on the results of Cox regression analysis. Multivariate Cox model showed that predictive factors of HCC development were age, gender, preexisting cirrhosis, ALT, AFP, platelet count, HBeAg, and HBVDNA. Projected HCC risk score is sum total of each risk score in these nine parameters (range 0-24).

収録刊行物

  • 肝臓

    肝臓 56 (9), 477-481, 2015

    一般社団法人　日本肝臓学会

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