Hemoptysis due to Aspirin Treatment Alternative to Warfarin Therapy in a Patient with Atrial Fibrillation
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- Song Wei
- Respiratory Department, the First Affiliated Hospital with Nanjing Medical University, China
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- Cao Jia
- Department of Pharmacy, the First Affiliated Hospital with Nanjing Medical University, China
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- Xu Yazhou
- Department of Pharmacy, the First Affiliated Hospital with Nanjing Medical University, China
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- Han Zhonglin
- Department of Cardiology, the First Affiliated Hospital with Nanjing Medical University, China
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- Wen Hao
- Department of Pharmacy, the First Affiliated Hospital with Nanjing Medical University, China
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- Cui Xuefan
- Respiratory Department, the First Affiliated Hospital with Nanjing Medical University, China
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抄録
An 80-year-old female with a history of hypertension and atrial fibrillation had been receiving warfarin anticoagulant therapy and had stably maintained an international normalized ratio (INR) within the 2.0-3.0 range. Due to dental extractions, she was prescribed aspirin (100 mg/day) as an alternative therapy to warfarin. Three days later, the patient complained of hemoptysis without obvious inducement and the INR was 3.51. The aspirin was immediately discontinued and intravenous vitamin K was administered. Hemoptysis did not reappear and the INR returned to the normal limits. According to the Drug Interaction Probability Scale, a causal relationship between aspirin and warfarin and an increased INR value is possible.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 54 (20), 2615-2618, 2015
一般社団法人 日本内科学会