Association between Airflow Limitation Severity and Arterial Stiffness as Determined by the Brachial-Ankle Pulse Wave Velocity: A Cross-Sectional Study
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- Oda Masako
- Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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- Omori Hisamitsu
- Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan Department of Biomedical Laboratory Sciences, Faculty of Life Sciences, Kumamoto University, Japan
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- Onoue Ayumi
- Department of Biomedical Laboratory Sciences, Faculty of Life Sciences, Kumamoto University, Japan
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- Cui Xiaoyi
- Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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- Lu Xi
- Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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- Yada Hironori
- Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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- Hisada Aya
- Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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- Miyazaki Wataru
- Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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- Higashi Noritaka
- Japanese Red Cross Kumamoto Health Care Center, Japan
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- Ogata Yasuhiro
- Japanese Red Cross Kumamoto Health Care Center, Japan
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- Katoh Takahiko
- Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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抄録
Objective Chronic obstructive pulmonary disease (COPD) is often associated with concomitant systemic manifestations and comorbidities, such as cardiovascular disease. There are limited data regarding airflow limitation (AL) and atherosclerosis in Japanese patients, and the potential association between AL and arterial stiffness has not yet been investigated in Japanese patients. Therefore, the purpose of this study was to investigate the association between AL severity and arterial stiffness using the brachial-ankle pulse wave velocity (baPWV).<br> Methods This cross-sectional study included 1,356 subjects aged 40-79 years without clinical cardiovascular diseases who underwent a comprehensive health screening that included spirometry, the baPWV measurement, and blood sampling during medical check-ups in 2009 at the Japanese Red Cross Kumamoto Health Care Center. AL was defined in accordance with the Global Initiative for COPD criteria (forced expiratory volume in one second / forced vital capacity of < 0.7). A cut-off baPWV value of >1,400 cm/s was used for risk prediction and screening.<br> Results The average baPWV (SD) results were 1,578.0 (317.9), 1,647.3 (374.4), and 1,747.3 (320.1) cm/s in the patients with a normal pulmonary function, mild AL, and moderate-to-severe AL, respectively (p< 0.001). Using logistic regression models adjusted for the age, body mass index, smoking status, hypersensitive C-reactive protein levels, hypertension, hyperglycemia, and dyslipidemia, an increased baPWV (>1,400 cm/s) was significantly associated with moderate-to-severe AL compared with a normal pulmonary function (odds ratio=2.76; 95% confidence intervals, 1.37-5.55; p=0.004).<br> Conclusion Our results indicated an association between AL and increased arterial stiffness. Arterial stiffness may therefore worsen with an increase in the severity of AL.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 54 (20), 2569-2575, 2015
一般社団法人 日本内科学会
