Myocardial Shortening in 3 Orthogonal Directions and Its Transmural Variation in Patients With Nonobstructive Hypertrophic Cardiomyopathy

• Okada Kazunori

  Faculty of Health Sciences, Hokkaido University

• Yamada Satoshi

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Iwano Hiroyuki

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Nishino Hisao

  Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital

• Nakabachi Masahiro

  Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital

• Yokoyama Shinobu

  Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital

• Abe Ayumu

  Faculty of Health Sciences, Hokkaido University

• Ichikawa Ayako

  Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital

• Kaga Sanae

  Faculty of Health Sciences, Hokkaido University

• Nishida Mutsumi

  Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital

• Hayashi Taichi

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Murai Daisuke

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Mikami Taisei

  Faculty of Health Sciences, Hokkaido University

• Tsutsui Hiroyuki

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

抄録

Background:Although longitudinal strain (LS) is known to be reduced in patients with hypertrophic cardiomyopathy (HCM), it has not been elucidated whether or not circumferential strain (CS) is reduced. We aimed to determine whether multidirectional and layer-specific myocardial strain is reduced in patients with nonobstructive HCM.Methods and Results:Speckle-tracking echocardiography was performed in 41 HCM patients and 27 control subjects. Segmental and global LS and CS were measured in the inner, mid, and outer layers. Global LS was significantly lower in the HCM group than in controls in the inner (−10.3±2.9 vs. −14.8±2.0%, P<0.001), mid (−8.7±2.6 vs. −13.8±1.9%, P<0.001), and outer (−7.2±2.6 vs. −11.9±1.9%, P<0.001) layers. Global CS was preserved in the inner layer (−23.8±4.7 vs. −24.3±3.3%, P=0.69) but reduced in the mid (−10.3±3.1 vs. −13.3±2.5%, P<0.001) and outer layers (−6.7±2.3 vs. −8.6±2.3%, P=0.002). Differences in CS between the inner and outer layers correlated with segmental relative wall thickness (r=−0.20, P=0.002). Furthermore, only the absolute value of global CS in the inner layer positively correlated with left ventricular ejection fraction (r=0.32, P<0.01) among these multidirectional and layer-specific strains.Conclusions:In patients with HCM, not only the LS in all layers but also CS in the mid and outer layers was reduced, presumably reflecting impaired myocardial function. In contrast, CS in the inner layer was preserved, being associated with maintenance of chamber function. (Circ J 2015; 79: 2471–2479)

収録刊行物

• Circulation Journal

  Circulation Journal 79 (11), 2471-2479, 2015

  一般社団法人 日本循環器学会

キーワード

• Ejection fraction
• Hypertrophic cardiomyopathy
• Myocardial function
• Speckle-tracking echocardiography

詳細情報

• CRID: 1390282680085810944
• NII論文ID: 130005104889
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-15-0646
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 026815872
• PubMed: 26354501
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026815872
• Web Site: https://www.jstage.jst.go.jp/article/circj/79/11/79_CJ-15-0646/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016232436
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可