Three Cases of Obese Elderly Type 2 Diabetes Mellitus With Successful Glycemic Control by Long-Acting Once-Weekly Formulation of Exenatide Injected by Their Caregivers

DOI
  • Ando Takemasa
    Department of Endocrinology and Metabolism, Nagoya City West Medical Center
  • Yasui Sachie
    Department of Endocrinology and Metabolism, Nagoya City West Medical Center
  • Kimura Ryosuke
    Department of Endocrinology and Metabolism, Nagoya City West Medical Center

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Other Title
  • 介護者が実施する持続性エキセナチドで良好な経過を見た自己管理困難な肥満高齢2型糖尿病の3例

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Abstract

We evaluated the efficacy of weekly caregiver-administered subcutaneous exenatide in elderly and obese type 2 diabetic (T2D) patients in whom hypoglycemic agents alone were ineffective and who had difficulty with self-administration. Case 1 was a 75-year-old woman with an 8-year history of T2D who had been treated with basal supported oral therapy and whose HbA1c level had deteriorated to 11.5 %. After 9 months of weekly caregiver-administered subcutaneous exenatide supplemented with oral hypoglycemic agents (OHA), her HbA1c level improved to 6.7 %. Case 2 was a 67-year-old woman with a 20-year history of T2D treated with OHA, including sulfonylurea, with a HbA1c level of 7.3 %. After 6 months of weekly caregiver-administered subcutaneous exenatide supplemented with OHA, her HbA1c level improved to 5.9 %. Case 3 was a 79-year-old woman with a 30-year history of T2D treated with a premix insulin injection and whose HbA1c level had deteriorated to 9.1 %. After 4 months of weekly caregiver-administered subcutaneous exenatide supplemented with OHA, her HbA1c level improved to 7.5 %. Our results indicate that weekly caregiver-administered subcutaneous exenatide may be an alternative therapeutic option for elderly and obese T2D patients in whom treatment with hypoglycemic agents alone is ineffective and who have difficulty with self-administration.

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