Incidences of Herpes Zoster and Postherpetic Neuralgia in Japanese Adults Aged 50 Years and Older From a Community-based Prospective Cohort Study: The SHEZ Study
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- Takao Yukiko
- The Research Foundation for Microbial Diseases of Osaka University Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
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- Miyazaki Yoshiyuki
- The Research Foundation for Microbial Diseases of Osaka University
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- Okeda Masayuki
- The Research Foundation for Microbial Diseases of Osaka University
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- Onishi Fumitake
- The Research Foundation for Microbial Diseases of Osaka University
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- Yano Shuichiro
- The Research Foundation for Microbial Diseases of Osaka University
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- Gomi Yasuyuki
- The Research Foundation for Microbial Diseases of Osaka University
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- Ishikawa Toyokazu
- The Research Foundation for Microbial Diseases of Osaka University
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- Okuno Yoshinobu
- The Research Foundation for Microbial Diseases of Osaka University
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- Mori Yasuko
- Division of Clinical Virology, Kobe University Graduate School of Medicine
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- Asada Hideo
- Department of Dermatology, Nara Medical University School of Medicine
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- Yamanishi Koichi
- The Research Foundation for Microbial Diseases of Osaka University
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- Iso Hiroyasu
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
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Background: Many cross-sectional studies have examined the incidences of herpes zoster (HZ) and postherpetic neuralgia (PHN), but prospective studies in Japanese older adults are lacking. Therefore, we conducted a community-based prospective cohort study to determine the incidence in Japanese adults aged ≥50 years.<BR>Methods: We recruited 12 522 participants from Shozu County, Kagawa Prefecture, between December 2008 and November 2009 and followed participants for 3 years. When a subject presented with symptoms suggestive of HZ, they were examined at collaborating medical institutions and cooperated with onset and recovery surveys (eg, measurement of varicella zoster virus-specific immunity and a pain survey). The hazard ratios (HRs) of HZ and PHN according to sex and age were analyzed by Cox regression analysis with a significance level of 5%.<BR>Results: The incidence of HZ was 10.9/1000 person-years (men: 8.5/1000 person-years; women: 12.8/1000 person-years) and was significantly higher in women than in men (HR 1.5; 95% confidence interval, 1.2–1.8). The incidence of PHN was 2.1/1000 person-years (men: 1.7/1000 person-years; women: 2.4/1000 person-years), with no significant sex differences. A total of 19% of HZ cases progressed to PHN; no sex-specific difference in the proportion of PHN cases was observed.<BR>Conclusions: We clarified the accurate incidences of HZ and PHN in a population of Japanese older adults. These incidences increased with age. HZ incidence was higher in women than in men, while PHN incidence did not differ markedly between the sexes.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 25 (10), 617-625, 2015
日本疫学会