Esophageal Candidiasis as the Initial Manifestation of Acute Myeloid Leukemia

  • Komeno Yukiko
    Department of Hematology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Japan
  • Uryu Hideki
    Department of Hematology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Japan
  • Iwata Yuko
    Department of Hematology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Japan
  • Hatada Yasumasa
    Department of Gastroenterology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Japan
  • Sakamoto Jumpei
    Department of Ophthalmology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Japan
  • Iihara Kuniko
    Department of Pathology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Japan
  • Ryu Tomiko
    Department of Hematology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Japan

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抄録

A 47-year-old woman presented with persistent dysphagia. A gastroendoscopy revealed massive esophageal candidiasis, and oral miconazole was prescribed. Three weeks later, she returned to our hospital without symptomatic improvement. She was febrile, and blood tests showed leukocytosis (137,150 /μL, blast 85%), anemia and thrombocytopenia. She was diagnosed with acute myeloid leukemia (AML). She received chemotherapy and antimicrobial agents. During the recovery from the nadir, bilateral ocular candidiasis was detected, suggesting the presence of preceding candidemia. Thus, esophageal candidiasis can be an initial manifestation of AML. Thorough examination to detect systemic candidiasis is strongly recommended when neutropenic patients exhibit local candidiasis prior to chemotherapy.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 54 (23), 3087-3092, 2015

    一般社団法人 日本内科学会

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