Quantitative Analysis of Vascular Structure in Decellularized Liver Using 3D Computed Tomography
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- Shirakigawa Nana
- Department of Chemical Engineering, Faculty of Engineering, Kyushu University
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- Ideguchi Tadamitsu
- Department of Radiological Science, Bachelor of Health Science, Junshin Gakuen University
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- Ichikawa Kazuyuki
- National Hospital Organization Kumamoto Medical Center
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- Izumi Takahisa
- National Hospital Organization Kumamoto Medical Center
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- Higashi Michiko
- National Hospital Organization Kumamoto Medical Center
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- Yamamoto Shizunari
- National Hospital Organization Kumamoto Medical Center
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- Ijima Hiroyuki
- Department of Chemical Engineering, Faculty of Engineering, Kyushu University
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抄録
Recently, decellularized liver (DC-liver) has been developed as a scaffold for the generation of liver tissue because DC-liver has a vascular structure that is used for oxygen delivery. The structure has been evaluated by the appearance of the resin cast. In the present study, three-dimensional computed tomography was used to obtain images of the vascular structure. Imaging at the hepatic lobule level was achieved by coating the resin cast with a contrast dye or gold. We defined indices to evaluate blood vessel conformation and structure. The indices were measured and calculated from the images. The results suggest that DC-liver has a fine vascular structure quantitatively similar to that of native liver. This method is valuable for the development of whole liver engineering.
収録刊行物
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- Advanced Biomedical Engineering
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Advanced Biomedical Engineering 4 (0), 179-185, 2015
公益社団法人 日本生体医工学会
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詳細情報 詳細情報について
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- CRID
- 1390001205502539904
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- NII論文ID
- 130005113203
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- ISSN
- 21875219
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
