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- TEKRIWAL Anand
- University of Pennsylvania, Department of Neurosurgery University of Colorado School of Medicine and Graduate School of Neuroscience
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- BALTUCH Gordon
- University of Pennsylvania, Department of Neurosurgery
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抄録
For over two decades, deep brain stimulation (DBS) has shown significant efficacy in treatment for refractory cases of dyskinesia, specifically in cases of Parkinson’s disease and dystonia. DBS offers potential alleviation from symptoms through a well-tolerated procedure that allows personalized modulation of targeted neuroanatomical regions and related circuitries. For clinicians contending with how to provide patients with meaningful alleviation from often debilitating intractable disorders, DBSs titratability and reversibility make it an attractive treatment option for indications ranging from traumatic brain injury to progressive epileptic supra-synchrony. The expansion of our collective knowledge of pathologic brain circuitries, as well as advances in imaging capabilities, electrophysiology techniques, and material sciences have contributed to the expanding application of DBS. This review will examine the potential efficacy of DBS for neurologic and psychiatric disorders currently under clinical investigation and will summarize findings from recent animal models.
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 55 (12), 861-877, 2015
一般社団法人 日本脳神経外科学会