Boiogito Increases the Metabolism of Fatty Acids in Proximal Tubular Cells through Peroxisome Proliferators-Activated Receptor (PPAR) α Agonistic Activity

• Kobayashi Kyoko

  Department of Pharmacognosy, Tohoku Pharmaceutical University

• Matsuyama Wakana

  Department of Pharmacognosy, Tohoku Pharmaceutical University

• Arai Yuhei

  Department of Pharmacognosy, Tohoku Pharmaceutical University

• Koizumi Saho

  Department of Pharmacognosy, Tohoku Pharmaceutical University

• Shimizu Tatsuya

  Department of Pharmacognosy, Tohoku Pharmaceutical University

• Tomioka Rie

  Department of Pharmacognosy, Tohoku Pharmaceutical University

• Sasaki Kenroh

  Department of Pharmacognosy, Tohoku Pharmaceutical University

抄録

The promotion of fatty acid metabolism, to which peroxisome proliferators-activated receptor (PPAR) α contributes, has been suggested to participate in maintaining the function of renal proximal tubular epithelial cells (PTECs). The loading of fatty acids to PTECs could result in cell inflammation and cell death. A “Kampo” medicine, Boiogito (BO), is used to treat overweight women exhibiting chronic fatigue and edema in the lower extremities or knees. BO improves renal function by reducing the portion of fatty acids, thereby preventing damage to PTECs. In this study, BO and Astragalus Root (AsR), a constituent crude drug of BO, were administered orally to intravenously bovine serum albumin (BSA)-administered mice to evaluate the PPARα–cAMP responsive element binding protein (CREB) binding protein (CBP) complex binding activity and/or mRNA expression of PPARα, as quantified by enzyme-linked immunosorbent assay (ELISA) and/or polymerase chain reaction (PCR). Increases in PPARα–CBP complex binding activity and the expression of PPARα mRNA were observed not only in BO-administered mice but also in AsR-administered mice, accompanied by a decrease in the amount of renal fatty acid.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 39 (1), 143-147, 2016

  公益社団法人 日本薬学会

キーワード

• Boiogito
• peroxisome proliferator-activated receptor α
• fatty acid metabolism
• Astragalus Root
• proximal tubular cell

詳細情報

• CRID: 1390282679609052032
• NII論文ID: 130005116497
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b15-00678
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 027013188
• PubMed: 26725438
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027013188
• Web Site: https://www.jstage.jst.go.jp/article/bpb/39/1/39_b15-00678/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016233235
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可