Cordycepin Suppresses Thymic Stromal Lymphopoietin Expression via Blocking Caspase-1 and Receptor-Interacting Protein 2 Signaling Pathways in Mast Cells

• Yoou Myoung-schook

  Department of Pharmacology, College of Korean Medicine, Kyung Hee University

• Jin Mu Hyun

  Skin Research Center, Research Park, LG Household & Healthcare Ltd.

• Lee So Young

  Skin Research Center, Research Park, LG Household & Healthcare Ltd.

• Lee Sang Hwa

  Skin Research Center, Research Park, LG Household & Healthcare Ltd.

• Kim Byunghyun

  Skin Research Center, Research Park, LG Household & Healthcare Ltd.

• Roh Seok Seon

  Whoo Oriental Herb & Skin Research Society College of Korean Medicine, Daejeon University

• Choi In Hwa

  Whoo Oriental Herb & Skin Research Society Department of Oriental Dermatology, College of Korean Medicine, Kyung Hee University

• Lee Myeong Soo

  Whoo Oriental Herb & Skin Research Society Korea Institute of Oriental Medicine

• Kim Hyung-Min

  Department of Pharmacology, College of Korean Medicine, Kyung Hee University Whoo Oriental Herb & Skin Research Society

• Jeong Hyun-Ja

  Department of Food Technology and Biochip Research Center, Hoseo University

書誌事項

タイトル別名

• Cordycepin Suppresses Thymic Stromal Lymphopoietin Expression <i>via</i> Blocking Caspase-1 and Receptor-Interacting Protein 2 Signaling Pathways in Mast Cells

抄録

Cordycepin (3′-deoxyadenosine) is one of the active components isolated from Cordyceps militaris, and has been shown to have anti-inflammatory, anti-oxidant, anti-aging, and anti-cancer effects. Mast cell-derived thymic stromal lymphopoietin (TSLP) plays an important role in the pathogenesis of allergic inflammatory reactions. Here, we investigated the regulatory effect and mechanisms of cordycepin on the expression of TSLP in the human mast cell line, HMC-1 cells, and in the human keratinocyte cell line, HaCaT cells. Cordycepin significantly decreased the production and mRNA expression of TSLP through the inhibition of caspase-1 and nuclear factor-κB activation. Cordycepin also significantly reduced the phosphorylation of receptor-interacting protein 2 and inhibitory kappa B (IκB) kinase β. Cordycepin significantly decreased the production and mRNA expression of interleukin (IL)-8, IL-1β, IL-6, and tumor necrosis factor-α in activated HMC-1 cells. Moreover, cordycepin significantly decreased the levels of TSLP in activated HaCaT cells. Our studies suggest that cordycepin can be applied to the treatment of allergic inflammatory diseases exacerbated by TSLP.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 39 (1), 90-96, 2016

  公益社団法人 日本薬学会

キーワード

• cordycepin
• thymic stromal lymphopoietin (TSLP)
• mast cell
• caspase-1
• receptor-interacting protein 2

詳細情報

• CRID: 1390282679609053696
• NII論文ID: 130005116499
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b15-00631
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 027013092
• PubMed: 26725432
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027013092
• Web Site: https://www.jstage.jst.go.jp/article/bpb/39/1/39_b15-00631/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016233227
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可