The caspase 3-dependent apoptotic effect of pycnogenol in human oral squamous cell carcinoma HSC-3 cells

DOI Web Site 参考文献30件
  • Yang In-Hyoung
    Department of Oral Pathology, School of Dentistry, and Institute of Oral Bioscience, Chonbuk National University
  • Shin Ji-Ae
    Department of Oral Pathology, School of Dentistry, and Institute of Oral Bioscience, Chonbuk National University
  • Kim Lee-Han
    Department of Oral Pathology, School of Dentistry, and Institute of Oral Bioscience, Chonbuk National University
  • Kwon Ki Han
    Department of Food Science and Nutrition, College of Health, Welfare and Education, Gwangju University
  • Cho Sung-Dae
    Department of Oral Pathology, School of Dentistry, and Institute of Oral Bioscience, Chonbuk National University

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In the present study, the apoptotic effect of pycnogenol and its molecular mechanism in human oral squamous cell carcinoma HSC-3 cells were investigated. Pycnogenol significantly inhibited the viability of HSC-3 cells and suppressed neoplastic cell transformation in HSC-3 cells and TPA-treated JB6 cells. It caused caspase-dependent apoptosis evidenced by the increase in cleaved poly (ADP-ribose) polymerase and caspase 3 in a dose-dependent manner. Pycnogenol increased Bak protein by enhancing its protein stability whereas other Bcl-2 family members were not altered. In addition, the treatment with pycnogenol led to the production of reactive oxygen species and N-acetyl-l-cysteine almost blocked pycnogenol-induced reactive oxygen species generation. Taken together, these findings suggest that pycnogenol may be a potential candidate for the chemoprevention or chemotherapy of human oral cancer.

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