Emergence of Daptomycin-Resistant <i>Staphylococcus aureus</i> during Treatment
-
- Hagiya Hideharu
- Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
-
- Haruki Yuto
- Department of Pharmacy, Tsuyama Chuo Hospital, Japan
-
- Uchida Taeko
- Department of Clinical Microbiology, Graduate School of Clinical Pharmacy, Shujitsu University, Japan
-
- Wada Tomoko
- Department of Pharmacy, Tsuyama Chuo Hospital, Japan Department of Clinical Microbiology, Graduate School of Clinical Pharmacy, Shujitsu University, Japan
-
- Shiota Sumiko
- Department of Clinical Microbiology, Graduate School of Clinical Pharmacy, Shujitsu University, Japan
-
- Ishida Tomoharu
- Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
-
- Ogawa Hiroko
- Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
-
- Murase Tomoko
- Department of Clinical Laboratory, Microbiology Division, Tsuyama Chuo Hospital, Japan
-
- Otsuka Fumio
- Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
この論文をさがす
抄録
A 68-year-old man with persistent bacteremia accompanying a large iliopsoas abscess, vertebral osteomyelitis, discitis and central venous port infection caused by methicillin-resistant Staphylococcus aureus (MRSA) was admitted to our hospital. During the course of treatment, the emergence of a daptomycin (DAP)-resistant MRSA strain was confirmed; the minimum inhibitory concentration was 1 to 2 μg/mL for vancomycin and more than 1 μg/mL for DAP. Although the bacterial cell wall was not significantly thickened, an increased positive surface charge and single-nucleotide polymorphism within mprF have been confirmed in DAP-resistant strains. Still rare, but clinicians need to be cautious of the emergence of DAP-resistant MRSA during treatment.<br>
収録刊行物
-
- Internal Medicine
-
Internal Medicine 55 (1), 73-78, 2016
一般社団法人 日本内科学会