From migration to settlement: the pathways, migration modes and dynamics of neurons in the developing brain
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- HATANAKA Yumiko
- Division of Cerebral Circuitry, National Institute for Physiological Sciences
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- ZHU Yan
- Division of Brain Function, National Institute of Genetics
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- TORIGOE Makio
- Lab Dev Gene Regulation, RIKEN, BSI
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- KITA Yoshiaki
- Lab Mol Mech Thalamus Dev, RIKEN BSI
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- MURAKAMI Fujio
- Graduate School of Frontier Biosciences, Osaka University
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Abstract
Neuronal migration is crucial for the construction of the nervous system. To reach their correct destination, migrating neurons choose pathways using physical substrates and chemical cues of either diffusible or non-diffusible nature. Migrating neurons extend a leading and a trailing process. The leading process, which extends in the direction of migration, determines navigation, in particular when a neuron changes its direction of migration. While most neurons simply migrate radially, certain neurons switch their mode of migration between radial and tangential, with the latter allowing migration to destinations far from the neurons’ site of generation. Consequently, neurons with distinct origins are intermingled, which results in intricate neuronal architectures and connectivities and provides an important basis for higher brain function. The trailing process, in contrast, contributes to the late stage of development by turning into the axon, thus contributing to the formation of neuronal circuits.
Journal
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- Proceedings of the Japan Academy, Series B
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Proceedings of the Japan Academy, Series B 92 (1), 1-19, 2016
The Japan Academy
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Keywords
Details 詳細情報について
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- CRID
- 1390282679123167616
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- NII Article ID
- 130005118553
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- NII Book ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL BIB ID
- 027076684
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- PubMed
- 26755396
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed