Intraindividual Crossover Comparison of Gadoxetic Acid Dose for Liver MRI in Normal Volunteers
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- MOTOSUGI Utaroh
- Department of Radiology, University of Wisconsin Department of Radiology, University of Yamanashi
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- BANNAS Peter
- Department of Radiology, University of Wisconsin Department of Radiology, University Hospital Hamburg-Eppendorf
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- HERNANDO Diego
- Department of Radiology, University of Wisconsin
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- SALMANI RAHIMI Mahdi
- Department of Biomedical Engineering, University of Wisconsin
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- HOLMES James H.
- Global MR Applications and Workflow, GE Healthcare
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- REEDER Scott B.
- Department of Radiology, University of Wisconsin Department of Biomedical Engineering, University of Wisconsin Department of Medical Physics, University of Wisconsin Department of Medicine, University of Wisconsin Department of Emergency Medicine, University of Wisconsin
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抄録
Purpose: We performed a quantitative intraindividual comparison of the performance of 0.025- and 0.05-mmol/kg doses for gadoxetic acid-enhanced liver magnetic resonance (MR) imaging.<br/>Materials and Methods: Eleven healthy volunteers underwent liver MR imaging twice, once with a 0.025- and once with a 0.05-mmol/kg dose of gadoxetic acid. MR spectroscopy and 3-dimensional gradient-echo T1-weighted images (3D-GRE) were obtained before and 3, 10, and 20 min after injection of the contrast medium to measure T1 and T2 values and signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) performance. During the dynamic phase, highly time-resolved 3D-GRE was used to estimate the relative CNR (CNRrel) of the hepatic artery and portal vein (PV) to the liver. We used paired t-tests to compare the results of different doses.<br/>Results: During the hepatobiliary phase, we observed shorter T1 values and higher SNRs of the liver (P < 0.001) and higher liver-to-PV and liver-to-muscle CNRs (P < 0.002) using 0.05 mmol/kg compared to 0.025 mmol/kg. Increasing the dose to 0.05 mmol/kg yielded a greater T1-shortening effect at 10 min delay even compared with 0.025 mmol/kg at 20 min (P < 0.001). During the dynamic phase, the peak CNRrel for the hepatic artery and portal vein were higher using 0.05 mmol/kg (P = 0.007 to 0.035).<br/>Conclusion: Use of gadoxetic acid at a dose of 0.05 mmol/kg leads to significantly higher SNR and CNR performance than with 0.025 mmol/kg. Quantitatively, a 10-min delay may be feasible for hepatobiliary-phase imaging when using 0.05 mmol/kg of gadoxetic acid.
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 15 (1), 60-72, 2016
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