Role of Zinc Transporter ZIP13 in Degenerative Changes in Periodontal Ligament and Alveolar Bone

• Idaira Yayoi

  Department of Pediatric Dentistry, Tsurumi University, School of Dental Medicine

• Munemasa Takaaki

  Department of Pediatric Dentistry, Tsurumi University, School of Dental Medicine

• Fukada Toshiyuki

  Molecular and Cellular Physiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University Department of Oral Pathology and Diagnostics, Showa University, School of Dentistry RIKEN Center for Integrative Medical Sciences

• Shimoda Shinji

  Department of Oral Anatomy, Tsurumi University, School of Dental Medicine

• Asada Yoshinobu

  Department of Pediatric Dentistry, Tsurumi University, School of Dental Medicine

抄録

ZIP13, a zinc transporter encoded by Slc39a13, acting on the homeostasis of zinc implicated in the biosynthesis and modification of collagen secretion, and the morphogenesis of connective tissues. This study aimed to determine the morphological changes in periodontal ligament and alveolar bone subjected to mechanical stress such as mastication, considering the functional role of ZIP13 in age-controlled periodontal tissue. Mandibles of wild type (WT) and knock-out (KO) mice were excised 2,4,6,12,20 and 50 weeks the periodontal ligament and alveolar bone surrounding the root of the first molar were subjected to light microscopy, transmission electron microscopy and immunohistochemistry. We found that the periodontium of KO mice exhibited several morphological changes such as connective tissues degenerative changes in during the early stage, suggesting that the lack of ZIP13 caused degenerative changes in homeostasis of collagen during the early stage, which could worsen upon application of mechanical stress. Consequently, ZIP13 was considered as one of the genetic factors in the control of the development and maturation of periodontal tissues.

収録刊行物

• Journal of Hard Tissue Biology

  Journal of Hard Tissue Biology 25 (1), 49-56, 2016

  硬組織再生生物学会

キーワード

• ZIP13
• Zip13-KO mice
• Periodontal ligament
• HE
• Collagen fiber

詳細情報

• CRID: 1390282679434698240
• NII論文ID: 130005119558
• NII書誌ID: AA11074332
• DOI: 10.2485/jhtb.25.49
• ISSN: 1880828X
• ISSN: 13417649
• NDL書誌ID: 027064295
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027064295
• Web Site: https://www.jstage.jst.go.jp/article/jhtb/25/1/25_49/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016292960
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可