Evaluation of Bone Regeneration by porous Alpha-Tricalcium Phosphate/Atelocollagen Sponge Composite in Critical-Sized Rat Calvarial Defects
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- Li Peiqi
- Department of Orthodontics, Osaka Dental University
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- Hashimoto Yoshiya
- Department of Biomaterials, Osaka Dental University
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- Honda Yoshitomo
- Institute of Dental Research, Osaka Dental University
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- Nakayama Yuji
- Department of Orthodontics, Osaka Dental University
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- Kobayashi Nobuhiro
- First Department of Oral and Maxillofacial Surgery, Osaka Dental University
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- Hara Eiki
- Department of Orthodontics, Osaka Dental University
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- Yasui Kenichirou
- Department of Orthodontics, Osaka Dental University
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- Arima Yoshiyuki
- Department of Orthodontics, Osaka Dental University
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- Matsumoto Naoyuki
- Department of Orthodontics, Osaka Dental University
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抄録
In periodontal surgery, autogenous bones are frequently used for bone transplantation. However, the application of autogenous bone is limited by the lack of sufficient donor sites and high possibility of resorption. In this study, we attempted to use the α-tricalcium phosphate/atelocollagen sponge composite (α-TCP/CS) to repair rat calvarial defects compared with that using autogenous bone. For the experiments, rats were divided into three groups. One group was filled with α-TCP/CS. Another was filled with autogenous bone, and control group remained unfilled. The rats were euthanized at 4, 6, and 8 weeks after surgery, after which the calvarial bone was scanned by micro-CT, and the histological examination was performed for evaluation of the bone tissue structures. In vivo micro-CT images at 8 weeks after surgery revealed that, in the α-TCP/CS group, the regenerative bone area was larger than in the autogenous bone group. Histological analysis revealed that α-TCP/CS was mostly absorbed at 8 weeks and a contiguous new bone was observed. This study demonstrated that composite sponges created from porous α-TCP/CS composite particles and atelocollagen were adaptable for treating bone defects.
収録刊行物
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 25 (1), 35-40, 2016
硬組織再生生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282679434702336
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- NII論文ID
- 130005119560
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- NII書誌ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- NDL書誌ID
- 027064282
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可