Preparation of Multi-Functional Molecularly Imprinted Polymer Receptors <i>via</i> Post-Imprinting Modifications

• TAKEUCHI Toshifumi

  Graduate School of Engineering, Kobe University

• SUNAYAMA Hirobumi

  Graduate School of Engineering, Kobe University Center for Collaborative Research and Technology, Kobe University

Bibliographic Information

Other Title

• 分子インプリンティングの新展開—ポストインプリンティング修飾による分子インプリント材料の多機能化
• 分子インプリンティングの新展開 : ポストインプリンティング修飾による分子インプリント材料の多機能化
• ブンシ インプリンティング ノ シン テンカイ : ポストインプリンティング シュウショク ニ ヨル ブンシ インプリント ザイリョウ ノ タキノウカ

Abstract

Molecular imprinting is a template polymerization to prepare functional materials capable of molecular recognition. Molecularly imprinted polymers (MIPs) can be simply prepared by copolymerization of a template molecule conjugated with functional monomers and cross-linkers. These robust and affordable synthetic polymer receptors are expected to be alternatives to biomacromolecules such as antibodies and enzymes. MIPs bearing a single function have matured so far, whereas preparation of multi-functionalized MIPs is still problematic due to the simple preparation protocols. Recently, we have proposed a new strategy, post-imprinting modification (PIM), to introduce additional functionality into MIPs and/or to improve molecular recognition activity by post-polymerization modification within the imprinted cavities, which was inspired by post-translational modifications during biosynthesis of proteins. In this paper, we describe an overview of PIM-based multi-functional MIPs, and introduce desirable functions such as off/on switching of molecular recognition activity, fluorescent reporting function for the binding events, catalytic activity and photo-responsive activity.

Journal

• KOBUNSHI RONBUNSHU

  KOBUNSHI RONBUNSHU 73 (1), 19-29, 2016

  The Society of Polymer Science, Japan

Keywords

• Molecular Imprinting
• Synthetic Polymer Receptor
• Post-imprinting Modification
• Bio-Inspired Materials
• Molecular Recognition
• Biomimetics

Details

• CRID: 1390001206526118912
• NII Article ID: 130005120383
• NII Book ID: AN00085011
• DOI: 10.1295/koron.2015-0054
• ISSN: 18815685
• ISSN: 03862186
• NDL BIB ID: 027080843
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027080843
• Web Site: https://www.jstage.jst.go.jp/article/koron/73/1/73_2015-0054/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed