マカクザルを用いた脊髄損傷からの回復過程についての多角的研究

• 澤田 真寛

  自然科学研究機構生理学研究所認知行動発達機構研究部門 滋賀県立守山成人病センター脳神経外科

• 伊佐 正

  自然科学研究機構生理学研究所認知行動発達機構研究部門 総合研究大学院大学生命科学研究科

書誌事項

タイトル別名

• Multi-disciplinary Research on the Recovery from the Spinal Cord Injury in a Primate Model

抄録

  Spinal cord injury (SCI) causes multiple dysfunctions including motor paresis, chronic pain, and incontinence, which severely impairs patients’ quality of life. However, partial injury is frequently followed by the substantial recovery of motor function. Revealing the mechanism of such spontaneous recovery will be helpful for the development of new treatments such as regenerative therapy, brain machine interfaces, and robot suit rehabilitation, among others. Recently, we developed an SCI model, which shows complete recovery of finger dexterity, in the macaque monkey. In this model, the lateral corticospinal tract, which directly connects the brain with spinal motoneurons, was selectively transected. Here, we reveal elements of the neural mechanism for motor recovery at different hierarchical levels of the central nervous system. These findings were made possible by investigating our novel monkey model.

収録刊行物

• 脊髄外科

  脊髄外科 29 (2), 132-138, 2015

  日本脊髄外科学会

キーワード

• spinal cord injury
• finger dexterity
• macaque monkey
• corticospinal tract
• sensorimotor cortex

詳細情報

• CRID: 1390282680204202880
• NII論文ID: 130005121025
• DOI: 10.2531/spinalsurg.29.132
• ISSN: 18809359
• ISSN: 09146024
• Web Site: https://www.jstage.jst.go.jp/article/spinalsurg/29/2/29_132/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015398226
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可