Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-co-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method
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- Pathak Shiva
- College of Pharmacy, Yeungnam University
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- Gupta Biki
- College of Pharmacy, Yeungnam University
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- Poudel Bijay Kumar
- College of Pharmacy, Yeungnam University
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- Tran Tuan Hiep
- College of Pharmacy, Yeungnam University
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- Regmi Shobha
- College of Pharmacy, Yeungnam University
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- Pham Tung Thanh
- College of Pharmacy, Yeungnam University
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- Thapa Raj Kumar
- College of Pharmacy, Yeungnam University
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- Kim Min-Soo
- College of Pharmacy, Pusan National University
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- Yong Chul Soon
- College of Pharmacy, Yeungnam University
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- Kim Jong Oh
- College of Pharmacy, Yeungnam University
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- Jeong Jee-Heon
- College of Pharmacy, Yeungnam University
書誌事項
- タイトル別名
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- Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-<i>co</i>-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method
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Tacrolimus-loaded poly(lactic-co-glycolic acid) microspheres (TAC-PLGA-M) can be administered for the long-term survival of transplanted organs due to their immunosuppressive activity. The purpose of our study was to optimize the parameters of the electrospray method, and to prepare TAC-PLGA-M with a high payload and desirable release properties. TAC-PLGA-M were prepared using the electrospray method. In vitro characterization and evaluation were performed using scanning electron microscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy. Drug-loading efficiency was greater than 80% in all formulations with a maximum loading capacity of 16.81±0.37%. XRD and DSC studies suggested that the drug was incorporated in an amorphous state or was molecularly dispersed in the microspheres. The in vitro release study showed prolonged release patterns. TAC-PLGA-M with enhanced drug loading and prolonged-release patterns were successfully prepared using the electrospray method.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 64 (2), 171-178, 2016
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204178147328
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- NII論文ID
- 130005121719
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 027063784
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- PubMed
- 26833445
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可