Neuroimaging in autism spectrum disorders : 1H-MRS and NIRS study
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- Mori Kenji
- Department of Child Health & Nursing, Institute of Health Biosciences, Tokushima University Graduate School
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- Toda Yoshihiro
- Department of Pediatrics, Institute of Health Biosciences, Tokushima University Graduate School
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- Ito Hiromichi
- Department of Pediatrics, Institute of Health Biosciences, Tokushima University Graduate School
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- Mori Tatsuo
- Department of Pediatrics, Institute of Health Biosciences, Tokushima University Graduate School
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- Mori Keiko
- The Joint Graduate School in Science of School Education, Hyogo University of Teacher Education
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- Goji Aya
- Department of Pediatrics, Institute of Health Biosciences, Tokushima University Graduate School
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- Hashimoto Hiroko
- Department of Child Health & Nursing, Institute of Health Biosciences, Tokushima University Graduate School
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- Tani Hiroe
- Department of Child Health & Nursing, Institute of Health Biosciences, Tokushima University Graduate School
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- Miyazaki Masahito
- Department of Pediatrics, Institute of Health Biosciences, Tokushima University Graduate School
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- Harada Masafumi
- Department of Radiology, Institute of Health Biosciences, Tokushima University Graduate School
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- Kagami Shoji
- Department of Pediatrics, Institute of Health Biosciences, Tokushima University Graduate School
書誌事項
- タイトル別名
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- Neuroimaging in autism spectrum disorders: <sup>1</sup>H-MRS and NIRS study
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Using proton magnetic resonance spectroscopy (1H-MRS), we measured chemical metabolites in the left amygdala and the bilateral orbito-frontal cortex (OFC) in children with autism spectrum disorders (ASD). The concentrations of N-acetylaspartate (NAA) in these regions of ASD were significantly decreased compared to those in the control group. In the autistic patients, the NAA concentrations in these regions correlated with their social quotient. These findings suggest the presence of neuronal dysfunction in the amygdala and OFC in ASD. Dysfunction in the amygdala and OFC may contribute to the pathogenesis of ASD. We performed a near-infrared spectroscopy (NIRS) study to evaluate the mirror neuron system in children with ASD. The concentrations of oxygenated hemoglobin (oxy-Hb) were measured with frontal probes using a 34-channel NIRS machine while the subjects imitated emotional facial expressions. The increments in the concentration of oxy-Hb in the pars opercularis of the inferior frontal gyrus in autistic subjects were significantly lower than those in the controls. However, the concentrations of oxy-Hb in this area were significantly elevated in autistic subjects after they were trained to imitate emotional facial expressions. The results suggest that mirror neurons could be activated by repeated imitation in children with ASD. J. Med. Invest. 62: 29-36, February, 2015
収録刊行物
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 62 (1.2), 29-36, 2015
国立大学法人 徳島大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390001204244966912
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- NII論文ID
- 130005129690
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- NII書誌ID
- AA11166929
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- ISSN
- 13496867
- 13431420
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- PubMed
- 25817280
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
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- PubMed
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