Metabolomic analysis of low molecular weight substances released into medium from HEK293 cells treated with methylmercury

• Toyama Takashi

  Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

• Hwang Gi-Wook

  Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

• Naganuma Akira

  Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

抄録

This study attempted to identify substances that are driven out of HEK293 cells by methylmercury. Metabolomic analysis revealed that the levels of 3-phenylpropionic acid, citrulline, lactic acid, ornithine, proline and beta-alanine in the cell culture medium were increased by the treatment of cells with methylmercury. Address to the mechanism underlying the release of these substances will provide useful information to elucidate the toxicity mechanism of methylmercury.

収録刊行物

• Fundamental Toxicological Sciences

  Fundamental Toxicological Sciences 2 (5), 227-228, 2015

  一般社団法人 日本毒性学会

キーワード

• Methylmercury
• Metabolomic analysis
• Substances released from cells
• HEK293 cells

詳細情報

• CRID: 1390001205763610752
• NII論文ID: 130005131079
• DOI: 10.2131/fts.2.227
• ISSN: 2189115X
• Web Site: https://www.jstage.jst.go.jp/article/fts/2/5/2_227/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017000396
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可