Citrulline enhances methylmercury toxicity in HEK293 and C17.2 cells

• Toyama Takashi

  Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

• Hwang Gi-Wook

  Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

• Naganuma Akira

  Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

抄録

We identified 3-phenylpropionic acid, citrulline, lactic acid, ornithine, proline, and beta-alanine as low-molecular weight substances that are released from cells treated with methylmercury. In this study, we studied their effect on cellular sensitivity to methylmercury. Treating HEK293 and C17.2 cells with each of the six substances minimally affected the proliferation of both cell lines. Among these six substances, however, only citrulline slightly but significantly increased the sensitivity of C17.2 and HEK293 cells to low levels of methylmercury. Citrulline is thought to be a methylmercury toxicity-enhancing factor whose extracellular release is enhanced by methylmercury.

収録刊行物

• Fundamental Toxicological Sciences

  Fundamental Toxicological Sciences 2 (6), 229-231, 2015

  一般社団法人 日本毒性学会

キーワード

• Methylmercury
• Toxicity
• Citrulline
• HEK293 cells
• C17.2 cells

詳細情報

• CRID: 1390282680740571904
• NII論文ID: 130005131080
• DOI: 10.2131/fts.2.229
• ISSN: 2189115X
• Web Site: https://www.jstage.jst.go.jp/article/fts/2/6/2_229/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016381695
• 本文言語コード: en
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