Chlorogenic acid from honeysuckle improves hepatic lipid dysregulation and modulates hepatic fatty acid composition in rats with chronic endotoxin infusion

DOI Web Site 参考文献53件
  • Zhou Yan
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University
  • Ruan Zheng
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University
  • Wen Yanmei
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University
  • Yang Yuhui
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University
  • Mi Shumei
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University
  • Zhou Lili
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University
  • Wu Xin
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University Institute of Subtropical Agriculture, Chinese Academy of Sciences
  • Ding Sheng
    Institute of Nutrition and Food Safety, Center for Disease Control and Prevention of Jiangxi Province
  • Deng Zeyuan
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University
  • Wu Guoyao
    Department of Animal Science, Faculty of Nutrition, Texas A&M University
  • Yin Yulong
    State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University Institute of Subtropical Agriculture, Chinese Academy of Sciences

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Chlorogenic acid as a natural hydroxycinnamic acid has protective effect for liver. Endotoxin induced metabolic disorder, such as lipid dysregulation and hyperlipidemia. In this study, we investigated the effect of chlorogenic acid in rats with chronic endotoxin infusion. The Sprague-Dawley rats with lipid metabolic disorder (LD group) were intraperitoneally injected endotoxin. And the rats of chlorogenic acid-LD group were daily received chlorogenic acid by intragastric administration. In chlorogenic acid-LD group, the area of visceral adipocyte was decreased and liver injury was ameliorated, as compared to LD group. In chlorogenic acid-LD group, serum triglycerides, free fatty acids, hepatic triglycerides and cholesterol were decreased, the proportion of C20:1, C24:1 and C18:3n-6, Δ9-18 and Δ6-desaturase activity index in the liver were decreased, and the proportion of C18:3n-3 acid was increased, compared to the LD group. Moreover, levels of phosphorylated AMP-activated protein kinase, carnitine palmitoyltransferase-I, and fatty acid β-oxidation were increased in chlorogenic acid-LD group compared to LD rats, whereas levels of fatty acid synthase and acetyl-CoA carboxylase were decreased. These findings demonstrate that chlorogenic acid effectively improves hepatic lipid dysregulation in rats by regulating fatty acid metabolism enzymes, stimulating AMP-activated protein kinase activation, and modulating levels of hepatic fatty acids.

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